Physical activity in relation to surgical operations- Randomized Intervention Trials (PHYSSURG)

a) PhysSURG C – colorectal cancer

b) PhysSURG B – breast cancer

c) PhysSURG PABOS - obesity

Summary of protocols

Before elective surgery for colorectal, breast cancer or obesity respectively, patients are included after informed consent and randomized to either control – established preoperative routine or intervention – extra physical activity for 30 minutes daily at a level where the patient is short of breath but with retained ability to talk. The activity is at the preference of the patient but suggestions include walks, jogging, swimming and such like. For those undergoing colorectal surgery respiratory muscle training is included for the two weeks before operation. For all three trials a further four weeks of increased activity starts when the patient is discharged from hospital.

The hypothesis is that with 30 min daily extra physical activity in connection with surgery patients will return to work and/or experience of physical/mental well-being significantly earlier than the patients who underwent surgery without added physical activity.

Inclusion

PhysSURG C started inclusion in 2015 at Sahlgrenska University Hospital and SKAS/Skövde hospital. To date 530 patients have been included. A power calculation based on the first 100 randomized patients was conducted during a preplanned interim analysis, resulting in a cohort size of 620 patients.

PhysSURG B started inclusion in November 2016 at Sahlgrenska University Hospital and included 202 patients during the first year. A power calculation based on the first 100 randomized patients was conducted during a preplanned interim analysis, in July 2017. Last patient was included December 2018 making it 400 included patients total.

PABOS started inclusion in March 2017 at Sahlgrenska University Hospital, Södra Älvsborg hospital, Centrallasarettet Växjö, Blekingesjukhuset/Karlshamn, Mora hospital, Torsby Hospital and Lindesberg Hospital. A power calculation based on the first 150 randomized patients was conducted during a preplanned interim analysis, in September 2019. Last patient was included December 2019 making it 300 included patients total.

Documents

Protocols:

PABOS

PhysSURG C

Publications:

The effect of pre- and post-operative physical activity on recovery after colorectal cancer surgery (PHYSSURG-C): Study protocol for a randomised controlled trial.
Onerup A, Angenete E, Bock D, Börjesson M, Fagevik Olsén M, et al.
Trials 2017;18(212).

Contact:

PhysSURG C – colorectal cancer

Eva Haglind (P.I.)
E-mail: eva.haglind@vgregion.se

PhysSURG B – breast cancer

Jenny Heiman

Phone: +46 31-342 83 44

E-mail: jenny.heiman.@vgregion.se

PhysSURG PABOS - obesity

Monika Fagevik Olsén (P.I.)
E-mail: monika.fagevik-olsen@vgregion.se